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Animal studies have shown adverse fetal outcomes with GLP-1 agonists

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FDA Category 2 status AOD-9604 was previously nominated for inclusion under FDA's Category 2 list (substances proposed for compounding under research/evaluation)

This inhibition preserves cellular NAD+ levels by reducing their consumption, simultaneously increasing GLUT4 transporter expression and activating sirtuin 1, known as the "longevity gene." The compound exhibits high membrane permeability and selectivity without affecting related methyltransferases or NAD+ salvage pathway enzymes, creating targeted metabolic effects while maintaining cellular safety