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Jill James, Ph.D

Toxicol Rep 12:389396

(235) tested the sensitivity of 117 cancer cell lines to Erastin-induced ferroptosis and found that diffuse large B-cell lymphoma and clear cell renal cell carcinoma (ccRCC) were particularly sensitive to GPX4-regulated ferroptosis

Linus Pauling Institue, Oregon State University

Moreover, as previously discussed, in a cecal ligation and puncture (CLP)-induced polymicrobial sepsis model, the conditional depletion of GPX4 triggers excessive lipid peroxidation and aggravates systemic inflammatory response that reportedly rely on GSDMD-dependent pyroptosis rather than ferroptosis [12]
