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In the presence of iron ions, H 2 O 2 is further reduced through the HaberWeiss and Fenton reactions to form the highly reactive and toxic hydroxyl radical (HO ) (Lipinski 2011)

The clinical application of responsive nanomaterials must undergo rigorous regulatory review and approval

Regulatory requirements vary by location and should always be verified

mice Female Balb/c mice (Harlan, Somerville, N.J.) 4-6 weeks of age were injected via the tail vein (single bolus) with PBS or antibody drug conjugates (1C1 and 1F12 conjugated to MMAE with the vc linker, or conjugated to MMAF with the mc linker) at the following dose levels: the vcMMAE antibodies were at 40 mg/kg, 50 mg/kg, and 60 mg/kg

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