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Mice that were given the probiotic not only were able to swim longer, but they had less anxiety and lower levels of the stress hormone, cortisol

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Much controversy has arisen around overexpression in nematodes and Drosophila, but few attempts have been made to further characterize the tissue-specific roles and define activities of sirtuins in these genetic systems by manipulationfor example, 20 years after the initial studies, no tissue-specific role for nematodes SIR-2.1 has been reported to date

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