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In addition, indoxyl sulfate raises levels of proalpha1(I) collagen, tissue inhibitor of metalloproteinase-1, transforming growth factor-beta1, and free radicals in vascular endothelium and smooth muscle cells

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Interestingly, phosphocreatine was not detected in the plasma of both Phase-I and Phase II HSB (Table 1), indicating that the muscle and other tissues of the fish do not release phosphocreatine
