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In studies, several HCC cell lines, including HepG2, Huh7, HLE, HLF, and SNU, show enhanced proliferation in response to ROS induction

PMID: 66 SczepanikFSCGrossiMLCasatiMGoldbergMGlogauerMFineNet al

Burnett, B
doi: 10.1371/journal.pone.0145038

The role and relative importance of IGF-1 signaling likely differs between muscle atrophy models, and further studies are required to develop effective strategies to apply IGF-1 to treat muscle atrophy in human patients
