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Frude et al., 2020
Firstly, one of the most striking superiorities of roxadustat, in addition to its oral route of administration, is the ability to stimulate endogenous EPO gene expression, as substantially increasing serum EPO level within or near a physiological level ( Secondly, roxadustat is confirmed to correct renal anemia through improving iron metabolism (Figure 2)

[1] Additionally, the authors indicate that there is still a requirement for successful human trials to be completed prior to clinical translation as there are important differences between rodent and human physiology that could have a significant impact on the efficacy and safety of any agent

Clin Liver Dis 2014

In contrast, aging leads to a significant reduction in cell proliferation in both adult SGZ and SVZ (reviewed by (Rossi et al., 2008)
