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Moreover, PNCs exhibited transcriptomic and proteomic signatures, which suggested a substantially decreased oxidative phosphorylation (OXPHOS) rate, while GNCs were characterised by elevated levels of transcripts and proteins that ensure efficient OXPHOS and TCA-cycle progression (Figs

More specifically, vitamin B12 plays an important role in DNA synthesis, which itself is vital for cellular reproduction

Because physical separation and barriers such as the inner limiting membrane lie between the putative excitotoxic sites at retinal synapses and the sampled fluids, it is uncertain whether changes detected in these samples accurately reflect post-injury glutamatergic events occurring near BC-to-RGC synapses [56]
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