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It is widely distributed in the brain, gastrointestinal tract, liver, adipose tissue, pancreas, and other tissues and is among the core systems that regulate energy balance, glucose/lipid metabolism, and immune inflammation ( 4.2.1.1 Effects on the gutpancreatic islet axis The ECS bidirectionally regulates pancreatic secretory function, with the effect depending on the activated receptor subtype

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Like other drugs containing sulfonamides, sulfamethoxazole and trimethoprim injection can precipitate porphyria crisis and hypothyroidism