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3 Current Pharmaceutical Design (PMC)Sikiric P et al

The epidermal melanocytes are then stimulated to produce melanin as the tyrosinase inhibiting effect of GSH has been diminished.[9] So, the predominant mechanism of hyper pigmentation in vitamin B12 is hypothesised as 1) Deficiency of vitminB12 decreases the level of reduced glutathione, which activate tyrosinase and thus leads to transfer to melanosomes

Fox says that if your pet has a demonstrated medical need for supplementation, correcting vitamin B12 levels can: Improve appetite Address certain gastrointestinal issues Allow for necessary weight gain Improve metabolic abnormalities (if present) Vitamin B12 Deficiency in Dogs Vitamin B12 deficiency in dogs is something a veterinarian can only diagnose through lab work and physical assessment

PMID: 25756278 11 Evaluation of a New Sublingual Methylcobalamin Dosage Regimen for Childhood Vitamin B12 Deficiency

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