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The risk of renal adverse reactions was increased in patients with a history of renal impairment (the weight management trials included 65 patients with a history of moderate or severe renal impairment at baseline), and occurred more frequently during dose titration
In this review, we focused on additional research in numerous areas including microRNA (mi RNA), small interfering RNA (siRNA), plant RNAi transformation vector and transgenic RNAi plants, and off-target effects
doi: 10.1159/000501895
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doi: 10.1016/S1359-6446(03)02703-X
