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Habdous M, Herbeth B, Vincent-Viry M, Lamont JV, Fitzgerald PS, Visvikis S, et al

These studies demonstrate that DCA treatment causes loss of GSTZ1, which results in accumulation of potentially toxic phenylalanine and tyrosine catabolites that may be causally linked with the observed effects of DCA on peripheral nerve function

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GSH is synthesized in every cell of higher eukaryotes, although GSH synthesis and turnover rates, and intracellular concentrations differ among cells and tissues (Hahn et al., 1978