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Therefore, inhibiting angiogenesis has become an important strategy for cancer treatment [151,152,153,154]

Grx-mediated protein deglutathionylation results in the transient formation of a Grx-GSH-mixed disulfide, which, in the monothiol mechanism, is resolved by a second GSH molecule to restore the reduced form of Grx [146]
To experimentally test the significance of pentose cycling, we knocked out either transketolase (TKT) or transaldolase (TALDO1), two enzymes in non-OxPPP required for recycling but that do not directly produce NADPH, in neutrophil-like cell line HL-60

[DOI] [PubMed] [Google Scholar] 122.Gouaze V, Andrieu-Abadie N, Cuvillier O, Malagarie-Cazenave S, Frisach MF, Mirault ME, Levade T

20103603120004), and Jiangxi Province Key Technology R&D Program (No