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High ROS levels induce reversible oxidative PTMs on critical thiol residues of ETC proteins (for example S-glutathionylation or S-nitrosylation of Complex I subunits), impairing electron transport efficiency and increasing electron leakage that further amplifies ROS production and lowers m (58)

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Understanding this oxidative stressSASP interplay highlights the need for therapeutic approaches that concurrently target mitochondrial health, redox balance, and SASP modulation
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