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NA cannot be salvaged into NAD + any longer if it is N-methylated by NNMT, so the methylation of NA impairs the abundance of free NAD + and then affects the activities of these NAD + -consuming enzymes [19]

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Collectively, the selenoprotein translation machinery consists of SECIS element, SBP2, Sec-specific eukaryotic elongation factor (EEFSEC), and aminoacylated Sec-tRNA [Ser]Sec , thereby enabling UGA to be recognized as a Sec codon and utilized for translation into the growing polypeptide

doi: 10.1038/s41531-020-00124-z 145 Santos-GarcaD.de FonticobaD