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Degenerating neurons occur in the cerebral and cerebellar cortices, and Wallerian degeneration in related white matter
Doctors use B12 shots as a last resort, such as if a supplement isn't working or a B12 deficiency causing severe symptoms

[DOI] [PubMed] [Google Scholar] Zeng Y., Xiang Y., Sheng R., Tomas H., Rodrigues J., Gu Z., Zhang H., Gong Q., Luo K

Both HMs damaged cellular bioenergetics with reductions of ATP production, mitochondrial complex activities, and aerobic respiration

and Weeraratna A.T