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GH exerts autocrine/paracrine effects by binding to GHR in the same or a neighboring cell surface and initiating JAK2- and SRC-mediated signaling cascades, which decrease pro-apoptotic molecules (Bax and PPAR) and suppress caspase protein activation (Figure 4A)

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"There is a century of data demonstrating that non-MOUD treatment is followed by a high rate of relapse to opioid use especially for morphine and heroin approaching 90% at six months (Musto, 1999, Broers et al., 2000, Heimer et al., 2019)

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Funding This work was supported by Health Commission of Anhui Province (AHWJ2021b111), Health Commission of Fuyang City (2021-1), and Anhui Medical University Fund Project (2021xkj210)