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In the case of semax, a peptide that the nominators said could treat migraines, nerve pain in the face and a serious condition called cerebral ischemia, where there is not enough blood flow to the brain, the FDA scientists found insufficient evidence to recommend it

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The exact involvement of the PAJ and its connective tissue in fibrosis development remains unclear, as well as how this microenvironment interconnects with inflammation to initiate and sustain fibrosis 15,16,17,18,19,20