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Future clinical studies should account for baseline choline status, microbiome profiles, genetic polymorphism in choline metabolic pathways, and organ-specific outcomes to define optimal strategies for leveraging the use of modulating choline availability and metabolism in personalized therapeutic interventions

Healthcare providers often add Lipo Plus to weight-management plans that include a balanced diet and regular exercise

Individuals at risk of choline inadequacy Daily intake recommendations are higher during pregnancy and lactation (see The AI), placing pregnant and lactating individuals at increased risk of choline inadequacy (25, 26)

doi: 10.1111/cns.12758 99 OkadaTMutoEYamanakaTUchinoHInazuM

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