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Firstly, combination therapy: The synergistic effects of combining these ESCM with conventional treatments (e.g., chemotherapy, radiotherapy, immunotherapy) should be investigated to enhance therapeutic efficacy and mitigate side effects

Heatmaps were generated using GraphPad Prism

Further, we performed differential abundance testing using DESeq2 with BenjaminHochberg adjustment

By limiting sebum production, it creates a skin environment less conducive to the proliferation of Cutibacterium acnes , a bacterium that worsens acne

Also, invasive therapies are associated with adverse effects including bleeding, infection, nerve damage, and blood clots (Douketis 2016a