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by enhancing NMDA-receptor function, high-dose glycine has been reported to influence symptoms in schizophrenia in some studies.) [2] [5] [6] Peripherally, glycine serves as a key building block and metabolic molecule

Moreover, DOX/aNLG919-loaded CaCO 3 nanoparticles (DNCaNPs) obtained by combining the ICD inducer DOX and the IDO1 inhibitor alkylated NLG919 can induce ICD in cancer cells and can induce effective anti-tumor immune responses by inhibiting IDO1 to limit the production of immunosuppressive kynurenine thereby leading to increased tumor cytotoxic CD8 + T cell infiltration and immunosuppressive Tregs depletion, and the combination of chemotherapy and immunotherapy with this nanoparticles can effectively inhibit tumor growth (168)

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doi: 10.1038/s41598-020-78935-6 204

Our further investigation reveals that the upregulation of GSH biosynthesis rather than dTTP is responsible for avoiding replication stress in T315I-Bcr-Abl cells