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In particular, myo-inositol modulated oral glucose tolerance tests (OGTTs) in polycystic ovary syndrome (PCOS) without familial diabetes, ALA increased insulin response to OGTT and metabolic parameters in all patients, and the combination of myo-inositol + ALA improved hormonal and metabolic aspects and insulin response to OGTT in all patients

GSH and GSSG recycling occurs via GPx and glutathione reductase, a process integral to regulation of ferroptosis, emerging as a contributor to neuronal death after TBI [45] and hemorrhagic stroke in mice [46]

Deviations in thyroid hormone levels have an implication on the gut microbiotas richness and composition, which is crucial for alterations in thyroid function as represented in the Fig

doi: 10.1038/s41598-017-02825-7

Free radicals and other oxidants are reduced by the direct action of GSH and indirectly via enzyme glutathione peroxidase, which use GSH as a cofactor