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doi: 10.1016/j.molmet.2018.09.005

In parallel, directly supporting the GSH/Trx systemsvia precursors (cysteine/N-acetylcysteine, selenium for selenoenzymes), enzyme cofactor support, or metabolic rewiringrestores redox buffering and helps the proteome re-enter the reversible cysteine zone (see The cysteine oxidation code section), preserving physiological H 2 O 2 -mediated signalling while preventing spillover into irreversible oxidation (Ren et al

The high titers were also associated with measurable GAD- antibodies in the CSF

Antibodies were subjected to accelerated stability testing by storing them at various temperatures (4C, room temperature, or 37C) for 1 week to mimic simulated shipping conditions and tested in immunostaining experiments

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