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Under normal physiological conditions, pigmentation has a beneficial effect on the photo-protection of human skin against harmful UV injury and plays an important evolutionary role in camouflage and animal mimicry 5

Furthermore, the selective clearance of different cargoes, such as lipids versus mitochondria, may be differentially impaired in the diseased liver, necessitating the development of cargo-specific flux measurements
The latency-associated UL138 gene product of human cytomegalovirus sensitizes cells to tumor necrosis factor alpha (TNF-) signaling by upregulating TNF- receptor 1 cell surface expression

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