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More serious but less common side effects to watch for at this dose include acute pancreatitis (symptoms: severe abdominal pain radiating to the back, nausea, vomiting), gallbladder problems (symptoms: sudden pain in the upper right abdomen, fever, jaundice), and significant hypoglycemia if combined with certain diabetes medications

Excipient-drug interactions in parenteral formulations

Up to 9000 puffs

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The last sailing ships built under Cabrillo's direction were the California exploration fleet: caravels, San Salvador (about 100 feet (30 m) long) and the smaller Victoria , and a bergantina (small sail boat or launch), San Miguel