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Talanta 122, 135139

120 There are three subtypes of IDH: IDH1 is located within the cytosol and peroxisomes, and IDH2/3 are primarily found in mitochondria

Cys and GSH levels were calculated by subtracting cystine and GSSG concentrations from free Cys and free GSH values

The toxicity of 5-azadC limits its clinical application, but combining it with histone deacetylase inhibitors like sodium butyrate has shown synergistic effects in FXS lymphoblastoid cell lines, leading to more effective restoration of FMR1 gene activity

again, oxidative stress is believed to be the culprit, with decreased GSTO gene expression resulting in a lowered age of onset for the diseases