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Rarely, and almost exclusively from injections rather than oral supplements

Via direct targeting of TREM2 (triggering receptor expressed on myeloid cells 2), Hecubine alleviated neuroinflammation and oxidative stress in both in vivo (4 dpf zebrafish larvae) and in vitro (BV-2 microglial cells) models, by modulating the Nrf2 and TLR4 signaling pathways (Figure 3C) (Li et al., 2024)

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C., et al., Cryoneurolysis versus Radiofrequency Ablation Outcome on Pain Experience in Chronic Low Back Pain (COPE): A Singleblinded Randomised Controlled Trial, RMD Open 10, no