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Anti-inflammatory Effect of Sulforaphane through the Suppression of COX-2 Expression Classical anti-inflammatory compounds such as aspirin, indomethacin, ibuprofen, and diclofenac as well as the newer generation of selective COX-2 inhibitors (e.g., celecoxib) target the enzymatic activity of COX-2, while others, including steroidal anti-inflammatory agents, suppress the induced expression of COX-2

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In the cell environment, these can promote ROS formation reacting with H 2 O 2 and generating highly reactive OH, in a series of Fenton and Fenton-like reactions

However, considerations in cost, lack of available preconditioning protocols, and potential side effects have limited its application in dogs