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Maeda et al

Weight loss peptide and ozempic alternative research

Inactivation of glutathione peroxidase by superoxide radical

Notably, BAs -mediated activation of FXR has been reported to suppress lipid peroxidation and inhibit ferroptosis

Co-treatment with cellular antioxidant agents including EUK-134 (6), resveratrol (84), curcumin (9), CoQ10 (90), dimethyl fumerate (DMF) (95), melatonin (64, 159), and -lipotic acid (160, 161), as well as mitochondrially specific antioxidants including Trolox (14), mitoQ (70), Mito-Tempo (87), and elampimide (13, 87), have been demonstrated to reduce or completely abrogate mitochondrial lesions, including lipid peroxidation, intrinsic apoptosis, and impaired ATP production in both in vitro and in vivo rodent models