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Tirzepatide is contraindicated in this group

While in some extremely severe and rapid progressing rare diseases it is feasible to overlook these problems, SCA3 has an adult onset and slow progression, making these issues important barriers to overcome

HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation

DISSECTION P2398 - ESOC25-1847 CEREBROCERVICAL ARTERY DISSECTION AS THE UNDERLYING CAUSE OF ACUTE ISCHEMIC STROKE: A PROSPECTIVE TEN YEAR STUDY Maria Chondrogianni 1 , Aikaterini Foska 1 , Athanasios Tsibonakis 1 , Aikaterini Theodorou 1 , Georgia Papagiannopoulou 1 , Konstantinos Melanis 1 , Klearchos Psychogios 2 , Odysseas Kargiotis 2 , Apostolos Safouris 2 , Eleni Bakola 1 , Maria Ioanna Stefanou 1 , Stefanos Lachanis 3 , Georgios Velonakis 4 , Lina Palaiodimou 1 , Georgios Tsivgoulis 1,5 1 Second Department of Neurology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, 2 Stroke Unit, Metropolitan Hospital, Piraeus, Piraeus, Greece, 3 Iatropolis Magnetic Resonance Diagnostic Centre, 15231, Athens, Greece, 4 Second Department of Radiology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, 5 Department of Neurology, University of Tennessee Health Science Center, Memphis, United States Background and Aims: Cervicocerebral artery dissection (CAD) accounts for nearly 2% of acute ischemic strokes (AIS), but this rate increases up to 25% in young ( 6 months)

Most patients notice changes within 24 weeks, though this varies by peptide and individual biology