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Cytoskeletal contraction and collapse: Abnormal cross-linking of the actin network causes cytoskeletal contraction and detachment from the plasma membrane, ultimately disrupting cellular morphology and structural integrity, triggering rapid cell death

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Abstract Cerebral ischemia-reperfusion (I/R) injury is a major contributor to mortality and long-term disability worldwide, primarily due to excessive reactive oxygen species (ROS) generation after blood flow is restored