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Levine DM, Parker TS, Donnelly TM, Walsh A, Rubin AL
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Alterations in methylation can lead to the elevation of homocysteine levels, called hyperhomocysteinemia which has been linked to a number of conditions related, but not limited to cardiovascular disease, neurological disorders and even cancer

Supplementation with Myo-Inositol and Selenium Improves the Clinical Conditions and Biochemical Features of Women with or at Risk for Subclinical Hypothyroidism
