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The short answer is Until you are satisfied with improvements in communication and the treatment no longer seems to be helping. Another useful response is, Consider discontinuing mB12 when stimming becomes more disruptive than language acquisition. I find it peculiar that parents pose this question at all

Mecobalamin supports healthy brain development and nerve function

Mistake #2: Skipping Inflammation Control and Expecting Regeneration Anyway Inflammation is not an enemy

In addition to its antioxidant activity, GSH has a variety of other functions including regulation of mitochondrial function, iron metabolism, immune cell polarization, cytokine production, and inflammatory signaling (Lu, 2013

Biomolecules , 10 (1), 40