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Once the remodeling program is running, the research rationale is that the signal can be sustained with less frequent reminders hence the step down to five, then two-to-three times weekly

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If you want to test it for yourself, keep the volume constant on two days, drink at two different temperatures, and time how long it takes to feel the first bladder urge
Always keep unopened vials in a dry, dark, and cool atmosphere with no direct sunlight
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