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IL-1, for example, increases AAV transduction efficiency in human synovial cells, suggesting that the OA microenvironment may be leveraged to improve delivery (183)

Kwon SH, Lee SR, Park YJ et al (2019) Suppression of 6-hydroxydopamine-induced oxidative stress by hyperoside via activation of Nrf2/HO-1 signaling in dopaminergic neurons

Formulation strategies that extend nasal residence time or enhance epithelial transport may also facilitate dose reduction while preserving therapeutic efficacy (Illum, 2003

NF-B in the liver--linking injury, fibrosis and hepatocellular carcinoma

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