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Skin adverse reactions were also reported, such as injection site pain, pruritus, rash, and urticaria, but only a few cases of acneiform eruptions [5]

[DOI] [PubMed] [Google Scholar] 75.Vadher K, Patel H, Mody R, Levine JA, Hoog M, Cheng AY, et al
Future nanoparticle studies may therefore need to consider risk-adapted approaches, including lower starting doses, gradual dose escalation, patient stratification based on genetic, vascular and imaging biomarkers, and serial neuroimaging surveillance (Lee et al., 2026)

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Rotate sites systematically using a pattern (e.g., alternating between right/left abdomen, right/left thigh) to avoid lipohypertrophy and maintain consistent absorption [9]
