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WD is caused by mutations in ATP7B , which encodes a transmembrane copper-transporting ATPase, leading to impaired copper homeostasis and copper overload in the liver, brain and other organs

TLRs are single-pass membrane-spanning receptors playing a key role in the innate immune system (187)

Indeed, the depletion of gpx4 in mice causes iron dysregulation, lipid peroxidation, hippocampal neurodegeneration and behavioral dysfunctions, suggesting that ferroptosis may be a key mechanism in AD diseases [79, 80]

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However, the faster it builds up, the worse you feel