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Regarding synergistic use with firstline chemotherapeutic agents, multiple studies confirm that natural products can enhance the efficacy of chemotherapy drugs while reducing their toxic side effects

Inhibiting monoamine oxidase (MAO) prevents the breakdown of monoamine neurotransmitters and is a primary mechanism of several herbal compounds

220 LPALPAR1 signaling regulates neurotransmitter release (e.g., tyrosine, glutamate, and GABA), and its disruption induces schizophrenia-like features in mice

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[18] reported no difference in dorsal ACC glutamate levels between treatment responsive and resistant groups