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Under oxidative stress these three systems work in concert to detoxify ROS and lipid peroxides, maintain protein structure and function via thiol repair, prevent activation of redox-sensitive inflammatory pathways, and preserve mitochondrial membrane integrity and prevent apoptosis

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doi: 10.3390/microorganisms11051232

Through the intensive study of the mechanical characteristics of native ECM in different tissues, researchers gradually began to explore the biomimetic biomechanical design of BNBMs in terms of cytocompatibility, proliferation and tissue repair for potential applications in modern TE and regenerative medicine [145147]