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Therefore the following symptoms of folate deficiency can also be a big indicator of a B12 deficiency such as: Anemia Eczema Cracked lips Prematurely greying hair Anxiety Tension Poor memory Lack of energy Poor appetite Stomach pains Depression What this means is your vitamin B12 levels can look good on paper after you have been to the doctor
Methylcobalamin intersects with methylfolate at the MTR enzyme, where both nutrients are required to stimulate the methionine pathway

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Association between serum vitamin B12 levels and the degree of steatosis in patients with non-alcoholic fatty liver disease

The term 'synergy' gets used when two compounds produce slightly better results together than alonebut true synergy means the combined effect exceeds the sum of individual effects, and that requires targeting rate-limiting steps in a shared pathway
