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The structural differences between these compounds create practical variations in how they deliver benefits, even though both support NAD+ metabolism

Regarding joint health, rapid release is more appropriate for acute needs, while the delayed-release formula works for more ongoing support

Peer review Peer review information Nature Communications thanks Nick Peake and the other anonymous reviewer(s) for their contribution to the peer review of this work

The differentiation from MSCs into osteoblasts/osteocytes seems to be melatonin dependent

The main mutagenic lesion is 8oxoguanine (8oxodG), which can base pair with adenine rather than cytosine and lead to transversion mutations once DNA replication is completed [86]