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In parallel, miR-124-3pcontaining exosomes can engage the STINGTBK1IRF3 signaling axis, inducing the production of type I interferons and further enhancing immune activation in the central nervous system (Hu et al., 2022)

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The exact mechanism is unknown, but there is evidence that TGF- inhibits B cell proliferation by inducing the transcription factor Id3, inducing expression of cyclin-dependent kinase inhibitor 21 (a regulator of cell cycle progression through the G1 and S phase), and repressing other key regulatory genes such as c-myc and ATM

The process is irreversible and is controlled by the activity of two enzymes: cystathionine beta-synthase (CBS) and cystathionine gamma-lyase, both of which require the active form of vitamin B6, pyridoxal 5-phosphate, to function