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An evidence-update on glutathione as a skin-lightening agent At the time of authoring this article, there were only four published studies that evaluated the efficacy of oral, topical, and parenteral glutathione as a skin-whitening agent (Table 1) [1013]

Trends Immunol 41:805

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Kaygusuzoglu E, Caglayan C, Kandemir FM, Yildirim S, Kucukler S, Kilinc MA, Saglam YS (2018) Zingerone ameliorates cisplatin-induced ovarian and uterine toxicity via suppression of sex hormone imbalances, oxidative stress, inflammation and apoptosis in female wistar rats

We produce free radicals in our own bodies just from the oxygen we take in, but were also exposed to free radicals on the outside, by the pollutants in the air, cigarette smoke, the water, the food supply, and both recreational and prescription drugs