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While the body stores a certain amount of B12, long-term deficiency can develop gradually, particularly in individuals with restricted dietssuch as vegansor those with medical conditions that impair absorption, such as pernicious anaemia or gastrointestinal disorders like coeliac disease or Crohns disease

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The exploitation of myofibroblast cell surface markers [175,182] or targeting their metabolic vulnerabilities [183] would be a unique approach around which more precise drug delivery methods could be developed

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