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Interestingly, the Zn II sensors Sa CzrA, 131 Bs CzrA, 255 Syn ZiaR 268 and Tt SmtB 130 that sense Zn II with significant specificity both in vivo and In vitro , 269 share the same DxHx 10 Hx 2 (H/E) motif with the Ni II sensor Mtb NmtR

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COMSTAT analysis of the CLSM images revealed significant reductions in biofilm biovolume ( Figure 2B ), significant increases in the DEAD/LIVE bacterial ratio ( Figure 2C ) and significant increases in biofilm roughness ( Supplementary Figure 1A ) when compared to the untreated control and nystatin-only treatment for all Candida strains tested (p 0.05)

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