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Additionally, SDF-1 inhibits GSK3 activation by binding to the specific receptor CXCR4 and activating the PI3K-Akt pathway, thereby enhancing -catenin gene expression and facilitating the recruitment of MSCs and endothelial progenitor cells to injury sites [70]

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Since its discovery by researchers at the University of Zagreb in 1993, this peptide has demonstrated remarkable healing properties across numerous preclinical studies

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