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Excessive acetyl-CoA production in the process of -oxidation inhibits the tricarboxylic acid (TCA) cycle, leading to mitochondria stress in hepatocytes [9, 10]
[DOI] [PMC free article] [PubMed] [Google Scholar] Leng Y., Chuang D.-M
Increased levels of species of Lactobacillus 87 and Streptococcaceae 88 are associated with increased intestinal inflammation and oxidative stress, which could affect both the periphery and CNS and thereby play a role in the exacerbated disease progression in the SOD1 + HFD mice (Figs
Jiao W, et al
