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Metal ions enter cells via specific transport proteins, such as copper transporter CTR1, or may be taken up through endocytosis, especially when metal nanoparticles or nano-drugs are used

Borneol downregulated the expression of PGP and increased the accumulation of rhodamine 123, an efflux pump ligand, in brain endothelial cells and the transport of digoxin and verapamil across the BBB model [110]

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Unlike GSH, GSSG does not stimulate the transport of other MRP1 substrates but rather inhibits it (102)

doi: 10.3899/jrheum.190009 47 StoltPKllbergHLundbergISjgrenBKlareskogLAlfredssonL