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TMAO is mainly derived from gut, where the gut microbiota converts TMA precursors into TMA, which is absorbed into the bloodstream through the intestinal mucosa, and then transformed into TMAO by hepatic flavin monooxygenases (FMOs) in the liver

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[DOI] [PubMed] [Google Scholar] 26.Tong F, Black PN, Coleman RA, DiRusso CC

Pathological chronic fatigue, on the other hand, operates on an entirely different biological axis
