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Recent developments have nonetheless provided new treatment options for patients with monogenic HTG as exemplified by the approval of Volanesorsen, an ApoC-III targeting drug, for the treatment of adults with FCS [141]

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Overcoming mutation-based resistance to antiandrogens with rational drug design

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Specifically, patients with melanosis seem to have greater than chance possibility of a family history of melanoma, a past personal history of melanoma (almost always at a nongenital site) and, on follow up, development of a melanoma (again, at a nongenital site)

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